Thursday, 16 July 2015

Embryo Stem Cells

Researchers conducted from embryonic stem cells, then from skin cells transformed into undifferentiated stem cells. This type of cell has the ability to redifferentiate in any other cell type, depending on how it stimulates.

From these cells, the researchers have managed to create cells corresponding to the first stages leading to gametes (eggs and sperm). Scientists are hopeful to see these precursors and immature cells develop into eggs and sperm, and lead to a viable embryo by fertilization.

But before being applied to humans, the experiment will be performed on mice. The latter will receive in their ovaries or testicles of egg and sperm precursor cells. Researchers hope that these cells will develop positively due to the influence of naturally occurring sex hormones in mice. After this successful stage, the tests will be extended to primates and then humans.

"The creation of germ cells at an early stage is one of the first events that took place in early mammalian development," says Dr. , lead author of the study. "This is a step that we have managed to recreate using mouse stem cells and rats, but until now, little research had managed it so using human stem cells. It revealed important differences between the embryonic development of humans and rodents, which means that the results obtained in mice and rats can not be extrapolated directly to human. "

If confirmed, this technique could allow an infertile person to create viable gametes from its stem cells, and no longer have to use a donor. Infertile or even infertile couples could then conceive a biological child in vitro. What revolutionize treatments for infertility, especially as oocyte donation and sperm are not always sufficient to meet the many demands.

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